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Turmeric Root
In a small clinical trial with participants taking 500mg of Turmeric 3x a day vs patients taking 50mg of Diclofenace (a leading anti-inflammatory drug). Scientists found both groups had significant pain relief, but the turmeric group had less issues. [1]
Glucosamine Sulfate
Glucosamine Sulfate acts as a building block for proteoglycans which give cartilage its viscoelastic (buffering properties). It has anti-inflammatory effects similar to NSAID drugs. Some studies show Glucosamine may inhibit breakdown and even improve cartilage. [2]
A study done in 2000 found Ginger to be as effective as ibuprofren. Another study in 2001 found ginger extract helped reduce knee pain upon standing and walking. A 2010 study found ginger to be as effective as pain reliever for muscle pain and exercise induced injuries. [3]
Chondroitin Sulfate
Chondroitin Sulfate has been shown to act as an anti-inflammatory to help reduce pain and some studies have shown it may help to slow cartilage breakdown and may even improve cartilage growth. [4]
Boswellia extract
Boswellia has been shown to be effective in helping to treat osteo-arthritis pain and inflammation. A small 2003 study found a decrease in knee pain, increase in knee flexion and the ability to walk farther. [5]
MSM studies show reduction in inflammation and reduction in pain in knees, back, hands and hips and improve overall quality of life. It has been shown to reduce the breakdown in cartilage that helps protect your bones and speeds muscle recovery after exercise. [6]
BioPerine is a patented extract obtained from black pepper, that has shown to be effective as an anti-inflammatory agent that helps reduce pain and discomfort. [7]
A study on Bromelain shows it has anti-inflammatory properties effective for pain relief, soft-tissue swelling and joint stiffness. [9]
Skullcap has been shown to improve mood and reduce anxiety symptoms by stimulating GABA (a neurotransmitter that helps calm nerves) [11]

[1] https://www.healthline.com/health-news/turmeric-may-be-as-effective-as-ibuprofen-for-relieving-arthritic-knee-pain-emb-2pm
[2] https://www.oaph.com/patient-resources/education/truth-about-glucosamine-and-chondroitin-sulfate
[3] https://www.healthline.com/health/ginger-for-arthritis#research
[4] https://www.oaph.com/patient-resources/education/truth-about-glucosamine-and-chondroitin-sulfate
[5] https://www.healthline.com/health/boswellia#oa
[6] https://www.healthline.com/nutrition/msm-supplements#TOC_TITLE_HDR_2
[7] https://www.formulatehealth.com/blog/bioperine-what-is-it-and-what-does-it-do
[8] https://pubmed.ncbi.nlm.nih.gov/27710596/
[9] https://www.healthline.com/health/bromelain#health-benefits

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