The Comprehensive Guide to Magnesium:
Heart Health and Beyond

magnesium deficiency

Magnesium is a vital mineral that plays a crucial role in over 300 enzymatic reactions in the body, including those involved in the regulation of heart health. This comprehensive guide delves deep into the benefits of magnesium, focusing on its contributions to cardiovascular health, particularly in managing blood pressure and cholesterol levels.

Understanding Magnesium

Magnesium is an essential mineral that is critical for bone health, proper nerve and muscle function, and maintaining a healthy immune system. It also helps regulate blood glucose levels and aids in the production of energy and protein. 

Magnesium and Heart Health

Cardiovascular diseases are a significant health challenge worldwide, and managing risk factors such as high blood pressure and cholesterol is essential for prevention.

Magnesium plays a significant role in cardiovascular health:

Blood Pressure: Magnesium helps relax blood vessels, which can reduce hypertension—a major risk factor for heart disease and stroke. Studies have shown that magnesium supplementation can lower blood pressure in people with hypertension【1】【2】.

Cholesterol Management: Adequate magnesium intake is associated with a better lipid profile. It can help lower levels of LDL cholesterol and triglycerides while boosting HDL cholesterol, thereby reducing the risk of arterial plaque buildup and cardiovascular diseases【3】【4】.

Broader Health Impacts of Magnesium

Bone Health: Magnesium is crucial for bone formation and influences the activities of osteoblasts and osteoclasts that build bone density. It also interacts with calcium and vitamin D in the body, nutrients that are vital for bone health【5】.

Diabetes Management: Magnesium plays a role in carbohydrate metabolism and the body’s ability to use insulin. Adequate magnesium intake is linked to a lower risk of type 2 diabetes【6】.

Migraine Prevention: Some studies suggest that magnesium can prevent and even help treat migraines. Magnesium deficiency is often seen in people who suffer from migraines【7】.

Anti-inflammatory Benefits: Low magnesium intake is associated with chronic inflammation, which is a driver of aging, obesity, and chronic disease. Supplementing with magnesium can reduce markers of inflammation in older adults and people with chronic diseases【8】.

Dietary Sources of Magnesium

Magnesium is abundantly available in a variety of foods, making it easy to include in your diet.

Rich sources include:

  • Green leafy vegetables, such as spinach and kale
  • Nuts and seeds, like almonds and pumpkin seeds
  • Legumes, including black beans and chickpeas
  • Whole grains, such as brown rice and whole wheat
  • Fortified foods, like certain breakfast cereals

Deficiency and Toxicity

Magnesium deficiency can manifest as fatigue, muscle cramps, mental problems, irregular heartbeats, and worsening of osteoporosis. It’s more common in individuals who consume a lot of processed foods and not enough fruits and vegetables. On the other hand, excessive magnesium intake from supplements can lead to gastrointestinal issues like diarrhea.

Types of Magnesium

Magnesium comes in various forms, each with specific benefits and potential drawbacks depending on your health needs and goals. Here’s a brief overview of some common forms of magnesium:

1. Magnesium Citrate
Magnesium citrate is one of the most popular forms of magnesium supplements due to its bioavailability and affordability. It combines magnesium with citric acid, which has a mild laxative effect. This makes magnesium citrate particularly effective for those dealing with constipation. However, the laxative effect might also be a drawback for those who have a sensitive digestive system or who are not looking for a laxative. Large amounts of Magnesium Citrate can deplete your body of important nutrients.

2. Magnesium Oxide
Often used in milk of magnesia products, magnesium oxide is typically marketed for relief from digestive complaints like heartburn and constipation. This form of magnesium provides a high level of elemental magnesium, but it is not as bioavailable as other forms. This means that while you get a lot of magnesium from magnesium oxide, your body may not absorb as much, which can be less efficient for addressing deficiencies.

3. Magnesium Glycinate
Known for its calming effects, magnesium glycinate is a chelated form of magnesium that binds magnesium to glycine. This form is highly bioavailable and less likely to cause laxative effects, making it ideal for those who need to supplement magnesium without the risk of digestive upset. Magnesium glycinate is often recommended for individuals looking to improve sleep or manage stress and anxiety.

4. Magnesium Malate
Magnesium malate, which combines magnesium with malic acid from fruits, is renowned for its high bioavailability and effectiveness in enhancing magnesium absorption and energy production. This form of magnesium participates in the Krebs cycle, a critical energy-generating process, which helps reduce muscle fatigue and boosts overall energy levels.

Its significant cardiovascular benefits stem from its ability to maintain normal muscle and nerve function, including those critical for heart health. Magnesium malate effectively manages blood pressure and supports heart’s electrical activity, ensuring a regular heartbeat and contributing to cardiovascular wellness. Studies indicate that adequate levels of magnesium from sources like magnesium malate are crucial for maintaining optimal blood pressure and overall heart health【9】【10】.

5. Magnesium L-Threonate
This newer form of magnesium is known for its ability to penetrate the mitochondrial membrane. Magnesium L-threonate is specifically touted for its benefits to brain health, potentially improving memory and cognitive function. Due to its targeted action, it’s one of the more expensive magnesium supplements, which could be a con for some users.

6. Magnesium Chloride
Extracted mostly from seawater, magnesium chloride is another highly absorbable form that can be used both orally and topically. It is often used in bath salts for muscle relaxation and recovery. However, its use might be limited by its bitter taste and its potential to cause skin irritation when used in high concentrations in topical applications.

Each of these forms of magnesium has its particular advantages, whether it’s enhanced bioavailability, specific health benefits, or cost-effectiveness. When choosing a magnesium supplement, consider what health benefits you are seeking and whether you have any specific health conditions that one form might address better than others. As always, it’s advisable to consult with a healthcare provider before starting any new supplement regimen.

Key Takeaways

Magnesium is essential for maintaining optimal health, with significant benefits for heart health through its effects on blood pressure and cholesterol levels. By including magnesium-rich foods in your diet or considering supplements when necessary, you can leverage these benefits to support your overall cardiovascular health.

TIKVA HEART and Magnesium

Recognizing the importance of magnesium in cardiovascular health, TIKVA HEART includes magnesium malate (the most easily absorbed and most beneficial for heart health)  in its formulation to help manage blood pressure and cholesterol, contributing to a reduced risk of heart disease.

To learn more about TIKVA HEART and all its benefits


[1] Journal of Clinical Hypertension: “Magnesium and Blood Pressure—A Meta-Analysis”
[2] American Journal of Clinical Nutrition: “Effects of Magnesium on Blood Pressure”
[3] Journal of the American College of Nutrition: “Impact of Magnesium on Cholesterol Levels”
[4] Nutrition Reviews: “Magnesium, Lipids, and Vascular Diseases”
[5] Osteoporosis International: “Magnesium and Bone Health”
[6] Diabetes Care: “Magnesium and Risk of Type 2 Diabetes”
[7] Headache: “Magnesium in Migraine Prevention”
[8] Anti-inflammatory and Anti-Allergy Agents in Medicinal Chemistry: “Magnesium and Inflammation”
[9] Journal of Human Hypertension: “Role of Magnesium in Cardiovascular Diseases”
[10] American Journal of Clinical Nutrition: “Bioavailability of Different Forms and Formulations of Magnesium”

My cart
Your cart is empty.

Looks like you haven't made a choice yet.