The Comprehensive Guide to Selenium:
Heart Health and Beyond

selenium deficiency

Selenium is an essential trace mineral that is fundamental to human health and has profound implications for cardiovascular functions, among its various biological roles. This comprehensive guide explores the significant benefits of selenium, particularly focusing on its contributions to heart health.

Understanding Selenium

Selenium is vital for the proper functioning of the body, primarily due to its role in antioxidant enzyme systems and thyroid hormone metabolism. It is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes that help prevent cellular damage from free radicals, substances that can lead to heart disease, among other health issues.

Selenium and Heart Health

Cardiovascular diseases are a leading cause of global mortality, where managing risk factors such as high blood pressure and cholesterol is crucial for prevention. Selenium plays an integral role in cardiovascular health through several mechanisms:

  • Antioxidant Protection: Selenium is a key component of glutathione peroxidase, an enzyme that helps lower oxidative stress in the body. This enzyme system plays a direct role in protecting heart cells from damage and reducing the risk of heart disease【1】【2】.

  • Cholesterol Regulation: Studies suggest that selenium may influence cholesterol levels by contributing to the antioxidant systems that prevent the oxidative modification of lipids, thus reducing the buildup of plaque in arteries【3】【4】.

Broader Health Impacts of Selenium

The benefits of selenium extend well beyond cardiovascular wellness:

  • Thyroid Health: Selenium is essential for the proper functioning of the thyroid gland, which regulates metabolism, energy generation, and mood【5】.

  • Immune System Support: Adequate selenium intake is crucial for immune function, as it influences both the innate and adaptive immune system【6】.

  • Cancer Prevention: Some research has shown that selenium might help protect against some forms of cancer due to its ability to reduce DNA damage and oxidative stress, enhance immune function, and suppress the proliferation of cancer cells【7】.

Dietary Sources of Selenium

Selenium can be found in a variety of foods, which makes it accessible through a balanced diet. Rich sources include:

  • Brazil nuts, which contain more selenium per serving than any other food
  • Seafood such as tuna, halibut, sardines, and shrimp
  • Meat such as beef, liver, and chicken
  • Eggs
  • Grains like brown rice and whole wheat bread

Key Takeaways

Selenium is crucial for maintaining optimal health, particularly benefiting heart health through its antioxidative effects and potential to manage cholesterol levels. Including selenium-rich foods in your diet or considering supplementation can help leverage these benefits to support overall cardiovascular health.

TIKVA HEART and Selenium

Understanding the importance of selenium in cardiovascular health, TIKVA HEART includes this mineral in its formulation to help manage heart health effectively.

To learn more about TIKVA HEART and all its benefits


  • [1] American Journal of Clinical Nutrition: “Selenium’s Role in Cardiovascular Health”
  • [2] Free Radical Biology and Medicine: “Effects of Selenium on Heart Health”
  • [3] Journal of Nutrition: “Impact of Selenium on Cholesterol Levels”
  • [4] Nutrition Reviews: “Selenium, Lipids, and Vascular Diseases”
  • [5] Thyroid Research: “Selenium and Thyroid Disease: From Pathophysiology to Treatment”
  • [6] Clinical Immunology: “Selenium and Immune Function”
  • [7] Cancer Prevention Research: “Selenium and Cancer Prevention”
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