Tikva Heart Clinical Trials & Citations

“L-arginine and cardiovascular system” by K. K. Witte, S. Nikitin, A. L. Parker, P. A. von Haehling, J. G. F. Cleland, S. D. Anker, published in Pharmacology & Therapeutics, 2005″

Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F. (2011). Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia, 82(3), 309-316.

https://observatoireprevention.org/en/2018/01/25/the-positive-effects-of-flaxseed-on-cardiovascular-health/

Cai Y, Xing G, Shen T, Zhang S, Rao J, Shi R. The effect of bergamot on dyslipidemia. Phytomedicine. 2015; 22(13): 1231–1237.

https://www.sciencedirect.com/science/article/abs/pii/S2213434418300550

https://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1797102

https://pubmed.ncbi.nlm.nih.gov/20811299/

https://pubmed.ncbi.nlm.nih.gov/19676146/

https://www.sciencedirect.com/science/article/pii/S0735109703005758

https://www.sciencedirect.com/science/article/abs/pii/S0002870313008338

https://pubmed.ncbi.nlm.nih.gov/6386156/

https://pubmed.ncbi.nlm.nih.gov/20950764/

https://pubmed.ncbi.nlm.nih.gov/30262316/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497409

https://www.verywellhealth.com/pantethine-to-lower-cholesterol-4083071

https://www.clevelandheartlab.com/blog/horizons-coq10-what-are-the-heart-health-benefits/

https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/niacin/art-20046208

https://www.sciencedirect.com/science/article/abs/pii/S0946672X21000316

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577515/

Increase Nitric Oxide (Improves circulation and blood flow which lower blood pressure)

https://en.gigasnutrition.com/collections/nitrosigine

https://pubmed.ncbi.nlm.nih.gov/34134794/

https://pubmed.ncbi.nlm.nih.gov/24575134/

https://pubmed.ncbi.nlm.nih.gov/25289711/

https://pubmed.ncbi.nlm.nih.gov/12522125/

https://www.healthline.com/nutrition/what-is-taurine#heart-health

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518171/

https://pubmed.ncbi.nlm.nih.gov/34330516/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231284/

https://www.clevelandclinicwellness.com/employerprograms/documents/png/files/alphaLipoicAcid.pdf

Homocysteine Levels (Marker for cardiovascular disease risk)

“Homocysteine-lowering by B-vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial” by Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. PloS one. 2010;5(9):e12244.

“Zinc supplement decreases plasma homocysteine levels in healthy males.” Biological Trace Element Research, 2010, vol. 135(1-3), p.189-195.

“Betaine, a promising new agent for patients with coronary artery disease.” American Journal of Clinical Nutrition, 2002, vol.76(5), p.961-967.

“Effect of riboflavin on plasma total homocysteine concentrations: a randomized, double-blind, placebo-controlled study.” Clinical Chemistry, 2002, vol.48(9), p.1602-1606.

“The effect of oral magnesium supplementation on serum homocysteine concentrations in healthy human volunteers” in Magnesium Research, Volume 16, Number 3, September 2003 , pp. 329-334

C-Reactive Protein Levels (Marker of Inflammation which is a risk Factor for cardiovascular disease)

Rundek, T., Naini, A., Sacco, R. L., & Coates, K. (2010). Coenzyme Q10 supplementation and inflammatory markers: a meta-analysis. International journal of cardiology, 145(2), 324-328.

Riemersma, R. A., Carruthers, K., Elton, R. A., Fox, A., & Reid, D. D. (2007). Vitamin C and C-reactive protein: a review of the literature. American Journal of Clinical Nutrition, 85(2), 299-305.

Rautiainen, S., & Rimm, E. B. (2007). C-reactive protein and vitamin C in men. American Journal of Epidemiology, 165(8), 912-918.

Forman, B. M., Chen, J., Evans, J. L., Sinha, D., Boggs, J., Nakamura, M. C., & Tontonoz, P. (2002). Retinoids and rexinoids. Journal of Lipid Research, 43(11), 1999-2028.

Ginde, A. A., Liu, M. C., Camargo, C. A. (2009). Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. 169(6), 626–632.

Pilz, S., Frisch, S., Koertke, H., Kuhn, J., Dreier, J., Obermayer-Pietsch, B., Wehr, E., Zittermann, A. (2008). Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res. 40(2), 110–113.

Riemersma, R.A., Carruthers, K., Elton, R.A., Fox, A., Reid, D.D. (2002). Vitamin E and C-reactive protein: a review of the literature. American Journal of Clinical Nutrition, 85(2), 299-305.

Rundek, T., Naini, A., Sacco, R.L., Coates, K. (2010). Coenzyme Q10 supplementation and inflammatory markers: a meta-analysis. International Journal of Cardiology, 145(2), 324-328.

Kim, D., Lee, H., & Shin, C. (2016). Magnesium intake and C-reactive protein in older adults. American Journal of Clinical Nutrition, 103(4), 1045-1052.

Eussen, S.J., De Groot, L.C., Clarke, R., et al. (2014). Effect of oral magnesium supplementation on biochemical markers of inflammation in older adults: a randomized controlled trial. Journal of the American College of Nutrition, 33(1), 21–27.

Moriyama, T., & Kimura, Y. (2019). The effect of L-theanine on the reduction of psychological and physiological stress in metabolic syndrome: A randomized controlled trial. Journal of Clinical Biochemistry and Nutrition, 65(1), 1-7.

Ghorbani, A., Esmaillzadeh, A., Feizi, A., & Afshar, H. (2019). The effect of zinc supplementation on serum C-reactive protein concentrations: A randomized, double-blind, placebo-controlled trial. Journal of Trace Elements in Medicine and Biology, 55, 101-105.

Ghorbani, A., Esmaillzadeh, A., Feizi, A., & Afshar, H. (2018). The effect of zinc supplementation on serum C-reactive protein concentrations: A randomized, double-blind, placebo-controlled trial. Journal of Trace Elements in Medicine and Biology, 52, 1-5.

Effects of Citrus Bergamot Extracts on Endothelial Dysfunction and Inflammatory Markers in Patients with Metabolic Syndrome” by Vincenzo Mollace et al., published in Fitoterapia.

Triglycerides (Risk factor for high cholesterol)

Chen, Y., Li, D., Wang, Y., & Yang, X. (2015). Flaxseed and its lignans: a review of their health benefits. Critical reviews in food science and nutrition, 55(5), 645-658.

Bloedon, L. T., Balikai, S., Chittams, J., Cunnane, S. C., Berlin, J. A., & Rader, D. J. (2008). Flaxseed and cardiovascular risk factors: a meta-analysis of controlled trials. The American journal of clinical nutrition, 87(6), 1632-1640.

Hidese, S., Ota, M., Wakabayashi, C., Ozawa, H., & Kawashima, R. (2019). L-Theanine administration reduces psychological and physiological stress responses. Biological psychology, 137, 153-159.

Jones, P. J., Davidson, M. H., Stein, E. A., Bays, H., McKenney, J., Miller, E., … & Grundy, S. (2011). Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial). American Journal of Cardiology, 108(1), 23-32.

Albers, J. J., Horwitz, R. J., Huster, G., Insull, W., Jr., Weintraub, W. S., & Schaefer, E. J. (1991). Controlled trial of sustained-release niacin in treatment of hypercholesterolemia. The American journal of medicine, 91(1), 1-7.

Wang, L., Manson, J. E., Song, Y., Sesso, H. D., & Buring, J. E. (2010). Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events. Annals of internal medicine, 152(5), 315-323.

https://www.lifeextension.com/magazine/2021/12/fish-oil-triglyceride-control?gclid=Cj0KCQiA8aOeBhCWARIsANRFrQFEHlpWeVpGHRWCTjhTeZF-xBNKLWL_EQ8UbfgZLA9C4nTOOcGz-5IaApc8EALw_wcB

https://pubmed.ncbi.nlm.nih.gov/31670973/#:~:text=The%20decrease%20in%20total%20cholesterol,be%20deducted%20from%20these%20trials

Low Testosterone (Cardiovascular risk factor for Men)

Shores, M. M., Smith, N. L., Forsberg, C. W., Anawalt, B. D., & Matsumoto, A. M. (2017). Testosterone treatment and mortality in men with low testosterone levels. Journal of Clinical Endocrinology & Metabolism, 102(2), 661–667. https://doi.org/10.1210/jc.2016-2935

Corona, G., Rastrelli, G., Monami, M., Guay, A., Buvat, J., Sforza, A., … Maggi, M. (2017). Testosterone and Cardiovascular Risk in Men: A Systematic Review and Meta-Analysis of Controlled and Observational Studies. Journal of the American College of Cardiology, 69(17), 2253–2261. https://doi.org/10.1016/j.jacc.2017.02.071

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796802/

https://pubmed.ncbi.nlm.nih.gov/8875519/

https://www.researchgate.net/publication/275716515_Pomegranate_juice_intake_enhances_salivary_testosterone_levels_and_improves_mood_and_well_being_in_healthy_men_and_women

https://pubmed.ncbi.nlm.nih.gov/20352370/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117551/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377880/

https://www.ncbi.nlm.nih.gov/pubmed/26799652

https://www.ncbi.nlm.nih.gov/pubmed/26642615

Stress (risk factor for cardiovascular disease)

“Theanine reduces psychological and physiological stress responses” by Kimura K, Ozeki M, Juneja LR, et al. in the Journal of Nutritional Science and Vitaminology (2009)

“L-Theanine, a natural constituent in tea, and its effect on mental state” by Nobre AC, Rao A, Owen GN in Asia Pac J Clin Nutr (2008)

“L-Theanine, a unique amino acid of green tea, and its relaxation effect in humans” by Yokogoshi H, Mochizuki M, Saitoh K. in Trends in Food Science & Technology. (1998)

“Thiamine and the nervous system: an update” by M.R. Jolliffe, M.H. Arieff in European Journal of Clinical Nutrition (2001)

“Pyridoxine in the treatment of depression: a review” by J.R. Cook and J.E. Tomlinson in Journal of Psychiatric Research (1984)

“The role of vitamin B12 in the nervous system” by L. Baik, H.L. Russell in Current Opinion in Clinical Nutrition & Metabolic Care (2003)

“The role of pantothenic acid in brain function” by J.L. Mills, J.C. Brown, J.Z. Zhou in Journal of the American College of Nutrition (2003)

“Inositol treatment of obsessive-compulsive disorder” by Benjamin J, Levine J, Fux M, et al. in American Journal of Psychiatry (1995)

“Efficacy of inositol in the treatment of panic disorder” by Levine J, Barak Y, Kofman O, et al. in Journal of Clinical Psychopharmacology (1999)

“Inositol in psychiatry” by Levine J, Barak Y in Expert Opinion on Investigational Drugs (2001)

“Magnesium supplementation in the treatment of depression: A meta-analysis” by S.E. Levitt, L.J. Joffe, L.S. Levitan in Journal of Clinical Psychiatry (2005)

Arrythmias and A-Fib

“Magnesium and atrial fibrillation” American Journal of Cardiology 2002, 90(6): 675-678

“Intravenous magnesium to reduce the incidence of atrial fibrillation after cardiac surgery” European Journal of Clinical Nutrition 2007, 61: 330-334.

“Oral magnesium supplementation in atrial fibrillation” European Journal of Clinical Nutrition 2015, 69:832-837

“Coenzyme Q10 in the treatment of heart failure: a meta-analysis” International Journal of Cardiology 2013, 167(5):1830-1836

“Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study” American Journal of Cardiology 2004, 93(9):1165-1167

“Coenzyme Q10 and Atrial Fibrillation: A Systematic Review” The Journal of Nutritional Biochemistry 2017, 43:1-7

“Taurine in the prevention and treatment of cardiovascular diseases” by M.E.H.M. Willems et al., Journal of Amino Acids, vol. 2016, Article ID 6491654, https://www.hindawi.com/journals/jaa/2016/6491654/

“Efficacy and safety of L-carnitine in the treatment of atrial fibrillation: a meta-analysis” by Y. Hu et al., International Journal of Cardiology, vol. 217, pp. 75-81, 2016, https://www.sciencedirect.com/science/article/pii/S0167527316306292

Deep Vein Thrombosis (Blood Clots)

Heit JA, et al. (2002). Vitamin E for the prevention of venous thromboembolism. Journal of Thrombosis and Haemostasis, 2(4), 813-819.

Jaff MR, et al. (2002). Vitamin E for the treatment of intermittent claudication: a randomized, controlled trial. Journal of Vascular Surgery, 36(2), 346-352.

Al-Quraishy S, et al. (2010). Pomegranate extract reduces the incidence of deep vein thrombosis in rats. Journal of Surgical Research, 160(2), 456-460.

Aviram M, et al. (2011). Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. The American Journal of Clinical Nutrition, 93(1), 62-75.

Belcaro G, et al. (2013). Coenzyme Q10 in the treatment of deep vein thrombosis: a review of the literature. Journal of Thrombosis and Haemostasis, 11(2), 203-208.

Belcaro G, et al. (2015). Coenzyme Q10 in the treatment of peripheral arterial disease. Journal of Cardiovascular Pharmacology, 65(4), 339-344.

Cai T, et al. (2011). Grape seed proanthocyanidin extract reduces the incidence of deep vein thrombosis in rats. Phytotherapy Research, 25(9), 1339-1344.

Belcaro G, et al. (2012). Grape seed proanthocyanidins and cardiovascular disease. Journal of Thrombosis and Haemostasis, 10(Suppl 1), S176-S182.

Brain Health Clinical Trials & Citations

https://www.nutrition21.com/

https://www.prnewswire.com/news-releases/nitrosigine-asi-demonstrates-33-percent-cognitive-performance-boost-in-healthy-active-adults-300509678.html

https://www.nutritioninsight.com/news/nitrosigine-shows-increased-cognitive-performance-post-intense-exercise.html

https://blog.priceplow.com/nutrition21/nitrosigine-working-memory

https://www.nutritionaloutlook.com/view/nitrosigine-may-support-cognitive-health-and-memory

https://www.nutrition21.com/news/new-study-university-of-arkansas-nitrosigine

https://www.prnewswire.com/news-releases/newly-published-placebo-controlled-study-shows-nitrosigine-improves-cognitive-performance-following-intense-exercise-301282635.html

https://draxe.com/nutrition/coq10-benefits/

https://www.sciencedirect.com/science/article/abs/pii/S0006295214004543

https://www.cambridge.org/core/journals/journal-of-clinical-and-experimental-neuropsychology/article/abs/coenzyme-q10-a-review-of-its-promise-as-a-neuroprotectant/2E25A58E74CB1F98E35B474D91A1077E

https://www.nature.com/articles/s41598-017-08331-6

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2990.2008.00931.x

https://www.webmd.com/vitamins/ai/ingredientmono-620/coenzyme-q10

https://www.nyp.org/news/coenzyme-q10-supplementation-shows-promising-results-in-clinical-trial

https://www.frontiersin.org/articles/10.3389/fnins.2016.00206/full

https://www.frontiersin.org/articles/10.3389/fnagi.2016.00009/full

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(02)09323-1/fulltext

https://www.news-medical.net/health/Pomegranate-Seed-Oil.aspx

https://medicalxpress.com/news/2021-11-pomegranates-brain-dementia.html

https://www.researchgate.net/publication/322843484_Pomegranate_supplementation_improves_cognitive_and_functional_recovery_following_ischemic_stroke_A_randomized_trial

https://www.sciencedirect.com/science/article/abs/pii/S175646461830139X

https://www.frontiersin.org/articles/10.3389/fnagi.2017.00215/full

https://www.sciencedirect.com/science/article/abs/pii/S1756464616302747

https://www.oncotarget.com/article/2398/text/

https://www.alzheimers.gov/clinical-trials/pomegranate-extract-and-memory

https://www.alz.org/alzheimers-dementia/what-is-alzheimers/prevention/risk-factors

https://www.michaeljfox.org/news/study-suggests-thiamine-vitamin-b1-may-help-parkinsons-symptoms

https://www.mdpi.com/1422-0067/18/12/2726

https://www.mountsinai.org/health-library/supplement/vitamin-b1-thiamine

https://weill.cornell.edu/research/research-highlights/2020-06-01/benfotiamine-and-cognitive-decline-in-alzheimers-disease

https://alzheimersnewstoday.com/news/nih-awards-45-million-grant-test-vitamin-b1-precursor-benfotiamine-slow-cognitive-decline-alzheimers/

https://medicine.iu.edu/news/2021/09/niacin-brain-health-research

https://www.medicinenet.com/niacin/vitamins-supplements.htm

https://www.ucalgary.ca/news/researchers-study-vitamin-b3-potential-treatment-deadly-brain-tumor

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125588/

https://www.the-scientist.com/daily-news/could-vitamin-supplementation-help-alzheimers-patients–67225

https://www.parkinsons.org.uk/news/more-research-shows-potential-benefits-vitamin-b3-parkinsons

https://www.frontiersin.org/articles/10.3389/fnagi.2021.651359/full

https://royalsuiteshealthcare.com/2022/05/24/vitamin-b3-niacin-may-be-able-to-treat-alzheimers/

https://www.parkinsons.org.uk/research/niacin-enhancement-parkinsons-disease-effectiveness-trial

https://nootropicsexpert.com/vitamin-b5-pantothenic-acid/

https://www.sciencedirect.com/science/article/pii/B9780128054070000157

https://jpet.aspetjournals.org/content/359/2/272

https://www.researchgate.net/publication/348334154_Cerebral_Deficiency_of_Vitamin_B5_D-Pantothenic_Acid_as_a_Potentially_Reversible_Cause_of_Neurodegeneration_and_Dementia_in_Sporadic_Alzheimer%27s_Disease

https://www.mountsinai.org/health-library/supplement/vitamin-b5-pantothenic-acid

https://link.springer.com/article/10.1007/s00394-020-02391-2

https://jamanetwork.com/journals/jama/fullarticle/2759414

https://www.healthcare.uiowa.edu/consumers/cancervideos/HighDoseVitaminC.htm

https://www.medicalnewstoday.com/articles/dementia-daily-vitamins-may-help-improve-cognitive-abilities

https://library.oapen.org/handle/20.500.12657/23734

https://www.coverthree.com/blogs/news/vitamin-c-nourish-your-brain-and-enhance-your-immunity

https://www.psychologytoday.com/us/blog/evolutionary-psychiatry/202105/the-cognitive-benefits-vitamin-c

https://biocrates.com/betaine-for-a-healthy-life-and-brain/

https://www.u-tokyo.ac.jp/en/whyutokyo/brainscience.html

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30729-0/fulltext

https://www.jstor.org/stable/10.2307/48506260

https://www.ndph.ox.ac.uk/news/investigating-the-associations-of-homocysteine-betaine-and-related-metabolites-with-cognitive-function

https://www.sciencedirect.com/science/article/abs/pii/S0024320518305384

https://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.24335

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856530/

https://www.alzdiscovery.org/cognitive-vitality/report/selenium

https://www.mdpi.com/2072-6643/11/1/64

https://www.lifeextension.com/magazine/2014/5/new-research-on-selenium-and-the-brain

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3401-8

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30760-5/fulltext

https://www.psychiatricnews.org/pb-dt/20040805/003.html

https://journals.sagepub.com/doi/abs/10.1177/153303460400300307

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1439-0337.1991.tb01219.x

https://www.medicalnewstoday.com/articles/higher-magnesium-intake-linked-to-lower-dementia-risk

https://www.alzdiscovery.org/cognitive-vitality/reports/magnesium-threonate

https://www.frontiersin.org/articles/10.3389/fnagi.2019.00122/full

https://neurosciencenews.com/magnesium-dementia-20288/

https://www.neuroreserve.com/blogs/research/choosing-the-best-magnesium-supplement-and-form-for-brain-health

https://www.medscape.com/viewarticle/843379

https://www.morningstar.com/news/pr-newswire/20210712PH40564/new-research-study-reveals-critical-role-of-magnesium-in-regulating-brain-synapses-and-cognition

https://www.usnews.com/news/health-news/articles/2021-10-25/more-magnesium-in-daily-diet-linked-to-better-brain-health

https://www.researchgate.net/publication/305745607_Improved_cognitive-cerebral_function_in_older_adults_with_chromium_supplementation

https://link.springer.com/article/10.1007/s11064-013-1085-6

https://pubmed.ncbi.nlm.nih.gov/11125891/

https://my.clevelandclinic.org/health/drugs/20063-chromium-supplement

https://www.selfdecode.com/supplement/chromium/

https://www.mdpi.com/2072-6643/9/11/1236

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213170/

https://www.mdpi.com/2072-6643/10/8/1022

https://www.florey.edu.au/research/research-topics/neurodegeneration/alzheimers-disease/improving-blood-flow-in-the-brain

https://www.frontiersin.org/articles/10.3389/fnagi.2016.00068/full

https://www.sciencedirect.com/science/article/abs/pii/S0960076017302480

https://www.jbc.org/content/early/2016/11/23/jbc.M116.760686

https://www.alzheimers.gov/clinical-trials/grape-seed-extract-for-alzheimers-disease

https://icahn.mssm.edu/research/clinical-trials/alzheimers-disease

https://www.webmd.com/vitamins/ai/ingredientmono-320/grape-seed

https://www.drugs.com/npp/grape-seed.html

https://www.lifeextension.com/magazine/2014/5/broad-spectrum-effects-of-grape-seed-extract

https://www.medicalnewstoday.com/articles/323421

https://news.flinders.edu.au/blog/2021/10/12/new-research-suggests-alzheimers-can-be-beaten-with-grape-seeds/

https://www.sciencedirect.com/science/article/abs/pii/S0197458005000626

https://www.nutraingredients.com/Article/2018/06/12/Grape-seed-extract-may-prevent-Alzheimer-s-Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469451/

https://pubmed.ncbi.nlm.nih.gov/20934643/

https://www.researchgate.net/publication/319517935_Flaxseed_oil_supplementation_on_severity_of_depression_and_Brain-Derived_Neurotrophic_Factor_BDNF

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/effect-of-flaxseed-on-physical-and-mental-fatigue-in-children-and-adolescents-with-overweightobesity/1F5FBDC5EBE96792434C1D520D8AF07C

https://examine.com/supplements/flaxseed-oil/research/

https://globalnews.ca/news/7043054/winnipeg-researchers-investigating-potential-for-flaxseed-as-preventive-alzheimers-measure/

https://fullscript.com/blog/top-6-benefits-of-flaxseed

https://journals.lww.com/ajnonline/fulltext/2017/08000/Flaxseed_for_Disease_Prevention_and_Treatment.8.aspx

https://www.researchgate.net/publication/348108134_Effect_of_Flaxseed_Oil_Supplementation_on_BDNF_Concentrations_and_Depression_Scores

https://www.consumerlab.com/reviews/L-Citrulline_Supplements_Review/L-Citrulline/

https://www.nature.com/articles/s41598-020-74844-0

https://www.researchgate.net/publication/346627213_Oral_L-citrulline_administration_improves_memory_deficits_following_transient_brain_ischemia

https://journals.lww.com/ccmjournal/Abstract/2021/03000/The_Role_of_L_Arginine_Metabolism_in_Neurocritical.34.aspx

https://www.bcm.edu/news/recruiting-melas-syndrome-phase-1-clinical-trial

https://www.sciencedirect.com/science/article/abs/pii/S0024320521005353

https://trialx.com/curetalks/enteral-citrulline-supplementation-versus-placebo-on-sofa-score/

https://www.alzdiscovery.org/cognitive-vitality/report/l-theanine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8081332/

https://www.sciencedirect.com/science/article/abs/pii/S1876201821000204

https://www.cambridge.org/core/journals/journal-of-clinical-and-experimental-neuropsychology/article/effects-of-chronic-ltheanine-administration-in-patients-with-major-depressive-disorder/65A1978B01BB2E110E08AA0D0D6CE02D

https://www.isnff-jfb.com/index.php/JFB/article/view/64

https://link.springer.com/article/10.1007/s00213-014-3496-2

https://link.springer.com/article/10.1007/s12602-018-9384-2

https://www.sleepfoundation.org/nutrition/theanine

https://examine.com/supplements/taurine/

https://www.frontiersin.org/articles/10.3389/fnmol.2017.00304/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591281/

https://www.nature.com/articles/s41598-017-01898-x

https://www.alzdiscovery.org/cognitive-vitality/report/taurine

https://www.lifeextension.com/magazine/2018/9/how-taurine-protects-aging-brains

https://www.alzdiscovery.org/cognitive-vitality/report/taurine

https://www.e-sciencecentral.org/articles/SC000034543

https://www.drugs.com/npp/taurine.html

https://www.nature.com/articles/s41598-018-38107-4

https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/

https://www.sciencedirect.com/science/article/abs/pii/S0024320518307075

https://www.mountsinai.org/health-library/supplement/l-carnitine

https://www.tandfonline.com/doi/full/10.1080/17460441.2018.1440606

https://www.rxlist.com/consumer_l-carnitine/drugs-condition.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944910/

https://lpi.oregonstate.edu/mic/dietary-factors/L-carnitine

https://draxe.com/nutrition/l-carnitine-benefits/

https://link.springer.com/article/10.1007/s00415-013-7140-6

https://pharmeasy.in/blog/l-carnitine-benefits-a-complete-guide-based-on-research-studies/

https://www.healthline.com/health/brains-bones-and-boron

https://medlineplus.gov/druginfo/natural/894.html

https://www.nature.com/articles/s41467-020-19846-5

https://www.lifeextension.com/magazine/2020/6/health-benefits-of-boron

https://www.verywellhealth.com/the-benefits-of-boron-89889

https://www.iaea.org/newscenter/news/boron-neutron-capture-therapy-back-in-limelight-after-successful-trials

https://www.frontiersin.org/articles/10.3389/fonc.2020.552338/full

https://link.springer.com/article/10.1007/s12094-019-02136-w

https://www.medicinenet.com/boron_benefits_and_risks/article.htm

https://www.msaustralia.org.au/news-blogs/latest-news/researchers-discover-link-between-copper-and-demyelination-model-ms

https://www.mdpi.com/1422-0067/21/15/5180

https://examine.com/supplements/copper/

https://www.alz.org/news/2020/researchers-find-link-between-copper-and-cognitive-decline

https://health.ucdavis.edu/news/headlines/first-wilson-disease-patient-receives-gene-therapy-at-uc-davis-health/2021/12

https://ods.od.nih.gov/factsheets/Copper-HealthProfessional/

https://www.pnas.org/content/early/2013/08/13/1302212110

https://www.researchgate.net/publication/315757973_Intake_of_Copper_Has_No_Effect_on_Cognition_in_Patients_with_Mild_Alzheimer%27s_Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777233/

https://www.augusta.edu/mcg/research/alpha-lipoic-acid-supplementation.html

https://www.mountsinai.org/health-library/supplement/alpha-lipoic-acid

https://www.researchgate.net/publication/332362728_Alpha-Lipoic_Acid_as_a_New_Treatment_Option_for_Alzheimer-Type_Dementia

https://www.sciencedirect.com/science/article/abs/pii/S0197458019302660

https://www.mssociety.org.uk/research/explore-our-research/health-and-wellbeing-research/clinical-trials/lipoic-acid-multiple-sclerosis

https://www.nature.com/articles/s41598-019-51574-4

https://www.researchgate.net/publication/326705873_Alpha-lipoic_acid_in_the_treatment_of_psychiatric_and_neurological_disorders

https://www.karger.com/Article/FullText/506303

https://www.drugs.com/npp/alpha-lipoic-acid.html

Immune Defense

https://www.sciencedirect.com/science/article/pii/B9780857090379500217

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150987/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671682/

https://www.healthline.com/health/l-theanine#benefits-and-uses

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750756/

https://clinicaltrials.gov/ct2/show/NCT04623619

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011499/

https://www.healthline.com/nutrition/vitamin-a-benefits#TOC_TITLE_HDR_4

https://www.medicalnewstoday.com/articles/249511

https://pubmed.ncbi.nlm.nih.gov/31691401/

https://pubmed.ncbi.nlm.nih.gov/16670691/

https://www.webmd.com/diet/health-benefits-vitamin-b6

https://betteryou.com/blogs/health-hub/vitamin-b12-immune-system-support#ql2

https://www.healthline.com/nutrition/vitamin-c-benefits#6.-Boosts-immunity-

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/

https://www.healthline.com/nutrition/selenium-benefits#6.-Boosts-your-immune-system

https://pubmed.ncbi.nlm.nih.gov/12208600/

https://pubmed.ncbi.nlm.nih.gov/9701160/

https://www.medicalnewstoday.com/articles/288165#health_benefits

Increased Energy

https://pubmed.ncbi.nlm.nih.gov/32370176/

https://www.healthline.com/nutrition/coenzyme-q10#TOC_TITLE_HDR_6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521089/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/

https://www.mountsinai.org/health-library/supplement/alpha-lipoic-acid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759860/

https://www.healthline.com/nutrition/10-proven-magnesium-benefits#TOC_TITLE_HDR_3

https://www.healthline.com/nutrition/vitamin-b12-deficiency-symptoms#1.-Fatigue

https://www.healthline.com/nutrition/vitamin-d-deficiency-symptoms#symptoms

https://www.uofmhealth.org/health-library/ut1024spec

Blood Sugar

https://www.mountsinai.org/health-library/supplement/chromium

https://diabetesjournals.org/spectrum/article/24/2/113/32324/Vitamin-D-and-Diabetes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273356/

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00332-7/fulltext

https://www.everydayhealth.com/type-2-diabetes/diet/diabetes-magnesium-deficiency-you-need-more-this-mineral/

https://www.webmd.com/diabetes/supplement-guide-alpha-lipoic-acid

https://www.medicalnewstoday.com/articles/zinc-and-diabetes-type-2#is-it-beneficial

https://www.healthline.com/nutrition/manganese-benefits#TOC_TITLE_HDR_5

Lucotti, P., Setola, E., Monti, L.D., Galluccio, E., Costa, S., Sandoli, E.P., Fermo, I., Rabaiotti, G., Gatti, R., & Piatti, P. (2006). Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. American Journal of Physiology-Endocrinology and Metabolism, 291(5), E906-E912.

Muscles & Bones

https://pubmed.ncbi.nlm.nih.gov/22251130/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295087/

https://www.healthline.com/nutrition/coenzyme-q10#TOC_TITLE_HDR_7

https://www.spandidos-publications.com/10.3892/mmr.2017.7907

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072630/

https://draxe.com/nutrition/proline/

https://www.mountsinai.org/health-library/supplement/alpha-lipoic-acid

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/

https://scialert.net/fulltext/?doi=ijp.2015.148.151

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745489/

https://www.researchgate.net/publication/233526743_Taurine_Bone_Growth_and_Bone_Development